Anti-allergic action of basic nonsteroidal antiinflammatory drugs on immediate hypersensitivity reaction in rats.

Use of Nonsteroidal Antiinflammatory Drugs

Clinical trial data have prompted questions about the degree to which patients and their physicians should consider an increased risk of cardiovascular or cerebrovascular events when selecting medications for pain relief. Since the 2005 publication of a Science Advisory on the use of nonsteroidal antiinflammatory drugs (NSAIDs) by the American Heart Association,1 several important events have o...

Meloxicam tolerance in hypersensitivity to nonsteroidal anti-inflammatory drugs.

BACKGROUND Patients with aspirin-sensitive respiratory and skin diseases experience cross reactions to all nonsteroidal anti-inflammatory drugs (NSAIDs) which inhibit cyclooxigenase (COX) enzymes. The need to identify an alternative drug that is safe and reliable is a common problem in clinical practice. OBJECTIVE The aim of this study was to test the tolerability of meloxicam in NSAID-sensit...

Colonic side effects of nonsteroidal antiinflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are a widely prescribed group of drugs, known to be responsible for many cases of gastroduodenal ulcers by inhibiting cyclo-oxygenase (1). The incidence of side effects while taking NSAID therapy is high, and has been reported to approach 70% in patients receiving long-term therapy. The most frequent complications are those involving the gastroduod...

Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs: An Update

After beta lactam antibiotics, hypersensitivity reactions to nonsteroidal antiinflammatory drugs are the second cause of hypersensitivity to drugs. Acute manifestations affect the respiratory tract (aspirin exacerbated respiratory disease), the skin (urticaria and angioedema), or are generalized (anaphylaxis). Correct diagnosis and treatment in order to prevent unnecessary morbidity and the pot...

Osteoarthritis: simple analgesics versus nonsteroidal antiinflammatory drugs.